Cashmere Anti-Aging Cream in Beverly Hills
People who take skincare seriously are past texture talk and vague promises. They want ingredients that do measurable work and a plan that respects tolerance, timing, and daily life in Los Angeles. That’s the bar for Cashmere, our prescription-strength, night-use cream built around tretinoin with supportive actives for tone, texture, and firmness.
At Physique26 in Beverly Hills, Cashmere is used as a medical topical inside a monitored routine—not a standalone cosmetic. The formula centers on tretinoin and layers GHK-Cu (copper peptide), niacinamide, and caffeine to target photoaging while guarding the barrier and keeping use realistic for high-demand schedules.
Cashmere is a physician-dispensed cream that pairs a retinoid with proven support ingredients. Tretinoin drives epidermal turnover and collagen signaling for lines, blotchy tone, and roughness. GHK-Cu helps with visible firmness and quality over weeks. Niacinamide supports barrier function and more even tone. Caffeine contributes to a tighter, less puffy look—especially around the eyes—so the skin reads more rested while deeper changes build.
This is structurally different from retail “cashmere” moisturizers that highlight plant antioxidants or resveratrol. Those can be elegant hydrators for morning routines, but they do not replace a supervised retinoid regimen.
Tretinoin: The backbone for photoaging. Used at night, titrated to tolerance, and always paired with SPF in the day.
GHK-Cu: A copper peptide used for visible firmness and texture over 8–12+ weeks.
Niacinamide: Barrier and tone support, commonly 2–5%, helpful during retinization.
Caffeine: Quick de-puffing and a subtle tightening feel; cosmetic benefit while longer-term changes accrue.
Tretinoin remodels; the supporting trio makes the process more livable and cosmetically rewarding. GHK-Cu signals repair, niacinamide steadies the barrier and oil balance, and caffeine sharpens the “you look rested” effect on busy mornings. Clinical literature on each ingredient is stronger than the head-to-head synergy data for the exact combination, so we rely on evidence for the parts plus in-clinic experience for the whole. The protocol, not just the product, is what keeps results consistent.
Cashmere suits patients with mild-to-moderate photoaging: fine lines, uneven tone, textural roughness, and a preference for evidence-based topicals they can stick with. It’s also a practical step-up for those moving from over-the-counter retinol to prescription tretinoin. We hold Cashmere during pregnancy or nursing and use caution with active eczema, barrier disruption, or intense sun exposure you can’t avoid (outdoor shoots, travel without shade management). A brief consult sorts out fit and timing.
Most patients start Cashmere at night, pea-size to the full face after cleanser, two to three evenings per week. If you’re comfortable after 10–14 days, increase frequency. Pair with a bland moisturizer on top if you feel tight. Daytime means broad-spectrum SPF, a vitamin C serum if you use one, and common-sense shade habits (hat, sunglasses, not baking at midday in Beverly Hills). If you’re on acids or exfoliating masks, rotate them to off-nights at first. Irritation that lingers gets a message to the team for adjustments.
The goal isn’t maximal concentration on day one; it’s consistent use over months. We’d rather you succeed on a tolerable cadence than cycle through flare-and-quit.
Weeks 2–4 often bring smoother texture and a more even surface. By 8–12 weeks, tone looks steadier and fine lines start to soften. Firmness and elasticity cues build more slowly and depend on adherence, sun behavior, and your baseline. Expect plateaus and step-ups; that’s normal for retinoids. The check-ins matter: tolerability tweaks, small frequency changes, or seasonal SPF coaching keep the graph moving in the right direction.
Tretinoin increases photosensitivity. Daily SPF isn’t negotiable. A little dryness or flaking early on is common and manageable with spacing, moisturizer layering, or a temporary pause. We avoid Cashmere during pregnancy or nursing. If you’re scheduling peels, microneedling, lasers, or resurfacing, we’ll set hold windows before and after so the skin behaves. If your routine already includes strong acids, benzoyl peroxide, or potent actives, we’ll map which nights go where to prevent unnecessary irritation.
Retail “cashmere” moisturizers lean into feel, hydration, and antioxidant stories. They’re good daytime companions under SPF and a reasonable add when you want comfort without downtime. Cashmere is built for work at night: prescription tretinoin as the driver, supported by GHK-Cu, niacinamide, and caffeine, rolled into a monitored plan with clear guardrails. Many patients use both—retail cream in the morning for comfort and barrier care, Cashmere at night for remodeling—so the skin reads rested while deeper change builds over weeks.
| Dimension | Cashmere (Tretinoin + GHK-Cu + Niacinamide + Caffeine) | Retail “Cashmere” Moisturizers (e.g., resveratrol, hydrators) |
| Primary purpose | Photoaging treatment: texture, tone, fine lines; collagen signaling; night work inside a protocol | Day comfort: hydration, antioxidant support; pairs with SPF |
| Core actives | Prescription tretinoin; GHK-Cu; niacinamide; caffeine | Resveratrol/plant antioxidants, emollients, humectants; no prescription retinoid |
| Evidence strength | Strong for tretinoin in photoaging; supportive literature for GHK-Cu and niacinamide | Antioxidant and moisturizing data; limited remodeling without a retinoid |
| Best timing | Night, on a cadence you can tolerate | Morning, under SPF; optional at night on “off” evenings if skin feels dry |
| Feel on skin | Treatment forward; may tingle, dry, or flake during ramp-up | Cushioned feel; immediate softness and glow |
| Onset of change | Weeks for texture; 8–12+ weeks for tone and fine lines; longer arc for firmness | Immediate comfort and radiance; long-term change modest without actives that remodel |
| Who benefits most | Mild–moderate photoaging; OTC retinol graduates; high-standards users who want clinical change | Normal–dry types wanting a comfortable AM layer; anyone needing extra moisture |
| Tolerability | Requires titration; buffer with moisturizer; short pauses around procedures | High tolerance; rare irritation unless fragrances or acids are present |
| Required pairings | Daily SPF; simple moisturizer; hold windows around peels/laser; message the team if irritation lingers | SPF still required; can layer over vitamin C; no special holds needed |
| Contraindications | Avoid during pregnancy or nursing; caution with active eczema or barrier injury | Broadly compatible; review if very sensitive or reactive |
| Oversight | Physician-dispensed; plan, titration, and follow-up | Retail; self-directed use |
In most cases, keep retail cream in the morning—cleanser, vitamin C, retail moisturizer, SPF—and reserve Cashmere for night. Start Cashmere two or three evenings per week, pea-size for the full face after cleanser; add a bland moisturizer on top if you feel tight. If your calendar includes peels, microneedling, or laser, hold Cashmere per the plan and lean on the retail cream plus SPF until skin is settled. When travel, shoots, or long days stack up, you can add the retail moisturizer on Cashmere off-nights so the barrier stays calm while the treatment cadence remains intact.
Skin improves faster when the rest of the plan is aligned. Mornings typically feature cleanser, vitamin C, moisturizer, and SPF. Evenings rotate Cashmere with off-nights for barrier repair as needed. If you’re in a GLP-1 program and noticing dullness or tone shifts during weight loss, we time devices and topicals to protect the barrier and keep progress visible. If travel or shoots are on the calendar, we adjust cadence so your face cooperates with your week, not the other way around.
Cashmere is dispensed through Physique26 after a brief consult. Refills follow once your tolerance and results are dialed in. This is typically self-pay; HSA/FSA documentation is available on request. Pickup is in Beverly Hills or shipped where compliant. If you’re already a Physique26 patient, Cashmere can be added at your next check-in.
Yes—vitamin C in the morning, Cashmere at night. That pairing covers daytime defense and nighttime remodeling without crowding the same window.
Tretinoin is prescription-strength with stronger evidence for photoaging. Expect a short adjustment period; we’ll set a tolerable cadence and support the barrier.
Many patients do, applied sparingly and avoiding the immediate lash line. If you’re sensitive, we’ll guide placement or step down frequency.
Texture usually improves within a few weeks. Tone and fine lines follow over 2–3 months, with firmness cues building beyond that. Consistency and SPF drive results.
Message the team. We’ll adjust frequency, add buffer moisturizer, or pause briefly. The plan is flexible so you can stay on it.
Yes, with timing. We set hold windows before and after in-office treatments to keep the barrier intact and outcomes predictable.
No. We’ll offer alternative routines that avoid retinoids during that period.
