
The wellness world has turned NAD+ into a catchall answer for everything from “better energy” to “longer life.” IV bars advertise quick hits. Supplements promise mitochondrial miracles. And somewhere in the middle of all that noise sits the actual molecule, nicotinamide adenine dinucleotide, a coenzyme your cells have relied on since day one.
People aren’t wrong to be curious. They’re just rarely given an honest explanation of what this therapy can and can’t do.
NAD+ is central to energy metabolism, DNA repair, and mitochondrial function. But delivery matters. Oral supplements often degrade in the gut, and IVs require hours in a chair and make you feel crummy afterwards. At Physique26 in Beverly Hills, we use NAD+ injections intentionally: a direct, efficient route for patients who want measured support for their brain, metabolism, and overall stamina.
NAD+ is not a wellness trend. It’s a coenzyme found in every cell in the body, involved in hundreds of metabolic reactions. The simplest way to think about it: without enough NAD+, your cells don’t convert fuel into usable energy efficiently. It sits inside the machinery that generates ATP, supports DNA repair, and helps regulate enzymes that influence how cells age and respond to stress.
Levels of NAD+ decline with age, chronic stress, poor sleep, heavy alcohol use, and certain illnesses. That drop doesn’t show up as a single symptom, but it can contribute to slower recovery, reduced stamina, more noticeable brain fog, and a general sense that your baseline is lower than it used to be.
This is why NAD+ has become a focus in longevity and performance medicine. The question is not “does the molecule matter?” It clearly does. The real question is how changing its availability might influence how you feel and function.

For patients at Physique26, the route of delivery is the difference between a supplement and a therapy.
Most over-the-counter products don’t contain NAD+ itself; they offer precursors like NR or NMN. That can be a valid approach, but it is indirect and depends heavily on your gut health and liver function.
NAD+ Injections bypass digestion entirely. When delivered intramuscularly, the molecule enters circulation in a controlled, bioavailable way. This supports whole-body energy metabolism, recovery, and cellular repair directly. Patients who respond often notice steadier daytime stamina, easier workout recovery, or a cleaner sense of “on” during long days of work—without the variability of a pill. Injections are also effective without the hang-over feeling NAD IV drips often cause.
Most of the interest in NAD+ comes from its role in energy metabolism. When NAD+ levels are sufficient, cells make ATP more efficiently, and that shows up in the way you think and move. None of this is dramatic. It’s the difference between forcing your brain into focus versus having the bandwidth to begin with.
Support During Weight Loss & GLP-1s On the metabolic side, NAD+ is a powerful partner to weight loss protocols. During calorie restriction, especially on GLP-1 medications, people often feel a drop in stamina or mental sharpness. NAD+ injections can help stabilize energy production during these phases so your output doesn’t dip as sharply as your intake.
The people who tend to explore NAD+ at Physique26 have usually tried foundational changes first. They sleep consistently. They train. They manage nutrition. And even with that structure in place, they notice their baseline slipping, longer ramp-up times in the morning, or slower recovery after demanding days.
For some, NAD+ becomes a way to evaluate whether mitochondrial support shifts that trajectory.
The through-line is intention. NAD+ works best for people who want a measured, medically evaluated trial, not a shortcut.

Safety with NAD+ is mostly about matching the right patient to the right dose. The molecule itself is familiar in medicine, but rapid dosing can be uncomfortable. Injections are generally well-tolerated and avoid the intense "flush" or nausea sometimes associated with rapid IV infusions.
There are situations where NAD+ isn’t the appropriate next step. Patients with active infections, uncontrolled chronic illness, or significant liver disease may need a different approach first. Pregnancy and breastfeeding are also exclusions. This isn’t meant to complicate the process. It’s meant to protect the experience.

NAD+ doesn’t feel like caffeine, and it doesn’t announce itself. Most patients describe the early phase as a subtle shift: mornings start with less friction, tasks feel easier to enter, and cognitive endurance stretches a little further into the afternoon.
By weeks four to eight, the trajectory becomes clearer. Patients who respond tend to show a pattern: steadier output, cleaner concentration, and less of the mid-day slide that used to be predictable. If the signal isn’t visible by the 12-week mark, we treat that as meaningful data. We stop or redirect. The goal is not to collect therapies. It’s to identify what genuinely supports your energy metabolism.
NAD+ Injections at Physique26 are offered as elective, self-pay services. There is no membership requirement and no complex contract.
Most patients start with a consultation to review history, medications, and current routine. Injections are administered in-clinic on a weekly schedule that fits your work and travel.
Why Physique26? NAD+ therapy lives in a grey area: too complex to be a casual wellness add-on, too hyped to be taken at face value. Physique26 exists in that middle space with a clear bias toward restraint. We don’t treat metabolic health in isolation. NAD+ is considered alongside GLP-1 use, B12 support, training load, and the demands of your actual life.
If you’re looking for a quick fix and a hashtag, this isn’t the right fit. If you want a medically grounded way to test whether NAD+ meaningfully improves how you think, move, and recover with a clear off-ramp if it doesn’t, this is exactly the kind of work Physique26 is built to do.
Some patients notice subtle changes in energy or focus within the first few sessions. For others, it takes several weeks of consistent weekly dosing to feel the shift in baseline.
Often, yes, and it can be highly beneficial. We review your protocol to ensure we are supporting your energy while you lose weight.
Injection site soreness is possible, as with any shot. Some patients may feel a very mild, transient warmth, but injections typically avoid the uncomfortable "chest pressure" associated with IVs.
Most protocols involve a weekly injection. Your provider will establish a schedule that aligns with your goals and travel needs.
No. NAD+ for performance and longevity is considered elective. Many patients use HSA or FSA funds to offset the cost.
It is an adjunct, not a replacement. However, many patients find they can stop taking oral NR/NMN supplements once they switch to the more direct injectable route.