GLP-1 Squared: Dual-Action Metabolic Therapy
Metabolic health is rarely solved by a single variable. For many patients, the barrier to significant weight loss isn’t just willpower or a lack of exercise—it is a complex physiological interplay of insulin signaling, gastric timing, and the neurological "noise" around food.
Modern medicine has given us powerful tools to address this. Semaglutide and tirzepatide have changed the landscape of weight management, helping millions move the needle on body weight and metabolic health. However, standard commercial protocols often force a choice between the two, locking individuals into a single pathway that may not fully address their unique medical needs.
GLP-1 Squared is Physique26’s answer to that limitation. It is a prescription-strength, custom-compounded protocol that combines the two most effective active pharmaceutical ingredients in metabolic medicine into a single formulation. By utilizing the strengths of both semaglutide and tirzepatide simultaneously, GLP-1 Squared offers a synergistic approach for those seeking robust, data-driven results.
GLP-1 Squared (GLP-1²) is the name for a compounded medication that combines two distinct drug ingredients: semaglutide and tirzepatide. Both are a type of drug known as a glucagon-like peptide-1 (GLP-1) receptor agonist, but they function in slightly different ways.
Instead of cycling between medications or guessing which receptor pathway will yield the best results, this hybrid formulation is intended to utilize the best aspects of each. It targets multiple receptor pathways at once, offering a comprehensive strategy for patients who need tighter control over hunger, cravings, and metabolic efficiency.
Because this specific combination is not available as a mass-produced commercial brand, GLP-1 Squared is a custom-compounded product. This means it is created by specialized compounding pharmacies that mix the active ingredients to precise standards, allowing for a level of customization that off-the-shelf drugs cannot match.
To understand why GLP-1 Squared is effective, you have to look at the biology of how these medications interact with the body.
Semaglutide acts primarily as a GLP-1 receptor agonist. Its primary strength lies in its ability to reduce "food noise," that constant mental chatter about what to eat next. It works by mimicking natural hormones that delay gastric emptying, keeping you feeling full for longer periods after a meal.
Tirzepatide is unique because it is a dual agonist. It targets both the GLP-1 receptor and the GIP (glucose-dependent insulinotropic polypeptide) receptor. This additional mechanism helps improve how the body processes sugar and fat. By engaging GIP receptors, tirzepatide supports insulin secretion in a glucose-dependent manner, which can further enhance metabolic health and weight loss outcomes.
When combined in GLP-1 Squared, these molecules work in concert. They mimic natural hormones to lower blood sugar, increase insulin secretion, and reduce hunger. This dual-action approach is designed to:
GLP-1 Squared is available by prescription only through a licensed provider and a state-licensed pharmacy. Because it is a compounded medication, understanding the source is critical for safety and effectiveness.
Compounding pharmacies play a vital role in modern medicine by creating medications tailored to the specific needs of patients—for example, removing allergens like dyes, creating specific liquid formulations for those who cannot swallow pills, or combining compatible active ingredients like semaglutide and tirzepatide.
However, not all pharmacies operate with the same rigor. At Physique26, we vet our partners extensively. We ensure that the compounding pharmacies we work with use high-purity active pharmaceutical ingredients and adhere to strict sterility and potency standards. We address common concerns regarding compounded drugs by prioritizing transparency: we know exactly where the medication comes from, how it is made, and the quality of the components used.
It is important to note that GLP-1 Squared acts as a custom formulation. While semaglutide and tirzepatide are FDA-approved as individual drugs for weight management or diabetes, the specific combined formulation in GLP-1 Squared is a compounded product and is not an FDA-approved drug itself. The FDA has noted concerns with some compounded GLP-1 drugs regarding dosing errors or improper salt forms used by less reputable companies. This is why Physique26 maintains rigid oversight of our supply chain, ensuring you receive a safe, effective product derived from legitimate sources.
GLP-1 Squared is not for everyone. It is a potent therapy reserved for patients with specific goals and medical profiles.
You might explore this option if:
Your safety is our priority. GLP-1 Squared is not suitable for individuals with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). It is also not prescribed for patients with a history of pancreatitis or significant active illness related to the gallbladder.
During your consult, your doctor or provider will review your medical needs and history to determine if this protocol is safe for you.
One of the key benefits of using a compounded formula like GLP-1 Squared is the ability to fine-tune dosing. Commercial pens often come in fixed, large jumps in dosage. If the next step up is too strong, the patient suffers; if the current step is too weak, progress stalls.
At Physique26, we utilize micro-titration. We prescribe doses that allow for smaller, more precise increments. This approach helps mitigate side effects like nausea while maintaining consistent weight loss. Dose adjustments are made based on your feedback, symptoms, and data—not a rigid manufacturer schedule.
How to Administer
GLP-1 Squared is typically dispensed in a vial. You will learn to self administer the medication via a subcutaneous injection (just under the skin) once a week.
As with other GLP-1 therapies, potential side effects can occur as your body adjusts to the medication. The most common issues are gastrointestinal, given how these drugs influence gastric emptying.
We monitor these symptoms closely. Because we can control the doses precisely, we can lower the amount temporarily to allow your system to acclimate, reducing the likelihood of severe nausea or vomiting that often leads patients to cancel treatment on standard protocols.
The risk with any powerful weight loss med is losing muscle alongside fat. When appetite drops significantly, protein intake often drops with it. If you lose weight but also lose the lean tissue that drives your metabolism, you are setting yourself up for long-term rebound.
At Physique26, we do not simply prescribe GLP-1 Squared and send you home. We build a body composition protocol around it. Additionally, we may recommend specific labs or testing to measure inflammatory markers or nutrient deficiencies that could hinder your progress.
We emphasize:
A common question regarding compounded therapies is insurance coverage. Because GLP-1 Squared is a custom-compounded medication and not a brand-name commercial drug, it is generally not covered by standard commercial insurance plans.
Most patients at Physique26 choose this option as a self-pay service. This allows for consistent access without the hassle of prior authorizations, denials, or supply shortages that frequently plague commercial pharmacy chains. We do not process insurance claims for this specific formulation, though you may be able to use HSA/FSA funds depending on your plan's rules.
GLP-1 Squared is available by prescription only.
Navigating the world of weight loss drugs can be overwhelming. There are endless websites offering quick scripts, but few offer the medical continuity required for safety and long-term success.
Physique26 is a physician-led practice. We do not view medicine as a transactional service. We view it as a partnership. Whether you are a founder needing cognitive clarity while dieting, or a patient struggling with inflammation and metabolic stalling, we utilize tools like GLP-1 Squared to help you build a physiology that serves your life.
We watch the details—sourcing, efficacy, side effects, and body composition—so you can focus on the results.
If you are looking for a comprehensive approach to weight loss that goes beyond the standard protocol, GLP-1 Squared may be the solution. Talk to the team at Physique26 to explore if this dual-action therapy is right for you. Visit our website or call our office to book your consultation today.
Yes. Buying "research peptides" online is risky; those products are often unregulated and may contain unknown fillers. GLP-1 Squared is prescribed by a licensed doctor or provider and sourced from regulated US-based compounding pharmacies using high-purity active pharmaceutical ingredients.
We only work with pharmacies that adhere to strict USP guidelines for sterility and potency. We can discuss our vetting process and the specific pharmacy used for your prescription during your visit.
Many patients find that the dual mechanism offers more robust appetite suppression and metabolic control, which can lead to more efficient weight loss. However, individual results vary based on age, biology, and adherence to lifestyle changes.
Contact us immediately. We can advise on dose adjustments, hydration strategies, or anti-nausea support. We are here to help you manage the process, not just dispense the drug.
Yes. The medication should generally be kept refrigerated, but it can withstand short periods of travel. We provide specific instructions on how to transport your vials safely.
While the ingredients (semaglutide and tirzepatide) are used to treat type 2 diabetes, GLP-1 Squared is often prescribed off-label for weight management. If you have diabetes, we will coordinate closely to monitor your glucose levels, as dose adjustments to other medications may be necessary.
